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Hepatitis C-Virus Infection and Risk of Coronary Heart Diseases

Received: 25 January 2014     Accepted: 8 April 2014     Published: 10 April 2014
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Abstract

Background: The world Health Organization has declared hepatitis C a global health problem, with approximately 3 % of the worldﹶs population. HCV infection was associated with a high risk of CHD. Hs-CRP and fibrinogen was considered as markers of coronary artery disease, their elevation correlated with incidence of CAD, However Apo A deficiency predict future risk of CAD. Aim: To study correlation between HCV infections and marker risk factors of coronary heart disease in different stages of liver disease. Patients & Method: Forty three chronic HCV patients were recruited at specialized hepatology clinic in National Hepatology and Tropical Medicine Research Institute (NHTMRI),Cairo; they were classified into 3 groups according to Child – Pugh score (A, B, C), 42 % were Child class A, 28 % Child B and 30 % Child C, age from 20 to 80 years. 15 healthy subjects served as control group. Detection of the following tests occurred for both groups: Liver function tests: ALT, AST, ALP, total protein, albumin, bilirubin, GGT and AFP. Ultra sensitive CRP, fibrinogen, apoprotein A and Lipid profile: Total Cholesterol, triglyceride, HDL-C, LDL-C, and Total Lipid. Results: the data obtained from results show that :liver enzymes AST, ALT, total bilirubin, albumin, total protein and INR levels were significantly different between groups and control (p< 0.05), Alkaline phosphates, GGT and AFP levels were not differing significantly in study groups and control (p> 0.05). Cardiac enzymes; CK and LDH levels were not significantly different between groups and control (p> 0.05). The APO A levels were not differs significantly in study groups and controls (p> 0.05). The fibrinogen andhs-CRP levels in the patients appeared to be significantly higher than those in the healthy controls (p< 0.05). Conclusion: hs-CRP and fibrinogen may be considered as a CHC progression prognostic factor, Evidence indicates that hepatitis C virus (HCV) have a key role in coronary heart disease.

Published in Clinical Medicine Research (Volume 3, Issue 2)
DOI 10.11648/j.cmr.20140302.18
Page(s) 44-49
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2014. Published by Science Publishing Group

Keywords

Fibrinogen, Cardiovascular Disease, Hs-CRP, Hepatitis C Virus, APO A

References
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  • APA Style

    Amin M. Abdel Baki, Nashwa A. Zaky. (2014). Hepatitis C-Virus Infection and Risk of Coronary Heart Diseases. Clinical Medicine Research, 3(2), 44-49. https://doi.org/10.11648/j.cmr.20140302.18

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    ACS Style

    Amin M. Abdel Baki; Nashwa A. Zaky. Hepatitis C-Virus Infection and Risk of Coronary Heart Diseases. Clin. Med. Res. 2014, 3(2), 44-49. doi: 10.11648/j.cmr.20140302.18

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    AMA Style

    Amin M. Abdel Baki, Nashwa A. Zaky. Hepatitis C-Virus Infection and Risk of Coronary Heart Diseases. Clin Med Res. 2014;3(2):44-49. doi: 10.11648/j.cmr.20140302.18

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  • @article{10.11648/j.cmr.20140302.18,
      author = {Amin M. Abdel Baki and Nashwa A. Zaky},
      title = {Hepatitis C-Virus Infection and Risk of Coronary Heart Diseases},
      journal = {Clinical Medicine Research},
      volume = {3},
      number = {2},
      pages = {44-49},
      doi = {10.11648/j.cmr.20140302.18},
      url = {https://doi.org/10.11648/j.cmr.20140302.18},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.cmr.20140302.18},
      abstract = {Background: The world Health Organization has declared hepatitis C a global health problem, with approximately 3 % of the worldﹶs population. HCV infection was associated with a high risk of CHD. Hs-CRP and fibrinogen was considered as markers of coronary artery disease, their elevation correlated with incidence of CAD, However Apo A deficiency predict future risk of CAD. Aim: To study correlation between HCV infections and marker risk factors of coronary heart disease in different stages of liver disease. Patients & Method: Forty three chronic HCV patients were recruited at specialized hepatology clinic in National Hepatology and Tropical Medicine Research Institute (NHTMRI),Cairo; they were classified  into 3 groups according to Child – Pugh score (A, B, C), 42 % were Child class A, 28 % Child B  and 30 % Child C, age from 20 to 80 years. 15 healthy subjects served as control group. Detection of the following tests occurred for both groups: Liver function tests: ALT, AST, ALP, total protein, albumin, bilirubin, GGT and AFP. Ultra sensitive CRP, fibrinogen, apoprotein A and Lipid profile: Total Cholesterol, triglyceride, HDL-C, LDL-C, and Total Lipid. Results: the data obtained from results show that :liver enzymes AST, ALT, total bilirubin, albumin, total protein and INR levels were significantly different between groups and control (p 0.05). Cardiac enzymes; CK and LDH levels were not significantly different between groups and control (p> 0.05). The APO A levels were not differs significantly in study groups and controls (p> 0.05). The fibrinogen andhs-CRP levels in the patients appeared to be significantly higher than those in the healthy controls (p< 0.05). Conclusion: hs-CRP and fibrinogen may be considered as a CHC progression prognostic factor, Evidence indicates that hepatitis C virus (HCV) have a key role in coronary heart disease.},
     year = {2014}
    }
    

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  • TY  - JOUR
    T1  - Hepatitis C-Virus Infection and Risk of Coronary Heart Diseases
    AU  - Amin M. Abdel Baki
    AU  - Nashwa A. Zaky
    Y1  - 2014/04/10
    PY  - 2014
    N1  - https://doi.org/10.11648/j.cmr.20140302.18
    DO  - 10.11648/j.cmr.20140302.18
    T2  - Clinical Medicine Research
    JF  - Clinical Medicine Research
    JO  - Clinical Medicine Research
    SP  - 44
    EP  - 49
    PB  - Science Publishing Group
    SN  - 2326-9057
    UR  - https://doi.org/10.11648/j.cmr.20140302.18
    AB  - Background: The world Health Organization has declared hepatitis C a global health problem, with approximately 3 % of the worldﹶs population. HCV infection was associated with a high risk of CHD. Hs-CRP and fibrinogen was considered as markers of coronary artery disease, their elevation correlated with incidence of CAD, However Apo A deficiency predict future risk of CAD. Aim: To study correlation between HCV infections and marker risk factors of coronary heart disease in different stages of liver disease. Patients & Method: Forty three chronic HCV patients were recruited at specialized hepatology clinic in National Hepatology and Tropical Medicine Research Institute (NHTMRI),Cairo; they were classified  into 3 groups according to Child – Pugh score (A, B, C), 42 % were Child class A, 28 % Child B  and 30 % Child C, age from 20 to 80 years. 15 healthy subjects served as control group. Detection of the following tests occurred for both groups: Liver function tests: ALT, AST, ALP, total protein, albumin, bilirubin, GGT and AFP. Ultra sensitive CRP, fibrinogen, apoprotein A and Lipid profile: Total Cholesterol, triglyceride, HDL-C, LDL-C, and Total Lipid. Results: the data obtained from results show that :liver enzymes AST, ALT, total bilirubin, albumin, total protein and INR levels were significantly different between groups and control (p 0.05). Cardiac enzymes; CK and LDH levels were not significantly different between groups and control (p> 0.05). The APO A levels were not differs significantly in study groups and controls (p> 0.05). The fibrinogen andhs-CRP levels in the patients appeared to be significantly higher than those in the healthy controls (p< 0.05). Conclusion: hs-CRP and fibrinogen may be considered as a CHC progression prognostic factor, Evidence indicates that hepatitis C virus (HCV) have a key role in coronary heart disease.
    VL  - 3
    IS  - 2
    ER  - 

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Author Information
  • Department of Tropical Medicine, National Hepatology and Tropical Medicine Research Institute, Cairo, Egypt

  • Department of Clinical Pathology, National Hepatology and Tropical Medicine Research Institute, Cairo, Egypt

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