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Surgical Treatment and Prognosis Analysis of Primary Carcinoma of Gallbladder

Received: 4 May 2017     Published: 4 May 2017
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Abstract

To discuss the effects of different treatment methods on the prognosis of primary carcinoma of gallbladder (PCG) patients. The clinical statistics of 99 cases of PCG patients were retrospectively analyzed, and the prognosis multivariate analysis was performed. Results: 52% of the patients suffered from PCG and gallstones simultaneously, and 82.8% (82/99) of the patients were diagnosed as PCG before surgeries. 86 cases of patients were subjected to routine exploratory surgeryies, and the radical resection rate was 33.72% (29/86). The overall 5-year survival rate was 6.28%, and the 1-year, 3-year and 5-year survival rates of the radical resection group were 78.43%, 48.49% and 23.77%, respectively. The results were significantly different from those of the palliative surgery group, the exploratory laparotomy group and the non-surgical group. The multivariate analysis of Cox model reveals that surgical method was significantly correlated with the invasion depth of tumor and the prognosis of gallbladder carcinoma. The treatment efficacy of PCG might be improved by increasing the early diagnosis rate and performing radical resection which are accompanied by radiotherapy and chemotherapy.

Published in Clinical Medicine Research (Volume 6, Issue 3)
DOI 10.11648/j.cmr.20170603.19
Page(s) 111-115
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2017. Published by Science Publishing Group

Keywords

Gallbladder Tumor, Surgery, Prognostic Factor

References
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[2] Ghosh M, Bhattacharyya NK, Ghoshsengupta S. Carcinoid tumour of gall bladder--a case report [J]. J Indian Med Assoc, 2011, 109 (3): 198-9.
[3] Kim K, Chie EK,et al. Postoperative chemoradiotherapy for gallbladder carcinoma [J].Strahlenther Onkol, 2012, 188 (5): 388-92.
[4] Pais-Costa SR, Farah JF, et al. Gallbladder adenocarcinoma: evaluation of the prognostic factors in 100 resectable cases in Brazil [J]. Arq Bras Cir Dig, 2012, 25 (1)13-9.
[5] Kim KH, Kim TN. Etiology, clinical features, and endoscopic management of hemobilia: a retrospective analysis of 37 cases [J]. Korean J Gastroenterol, 2012, 59 (4) 296-302.
[6] Yao X, Zhou L, Han S, Chen Y. High expression of CXCR4 and CXCR7 predicts poor survival in gallbladder carcinoma [J]. J Int Med Res, 2011, 39 (4): 1253-64.
[7] Wakai T, Ajioka Y,et al. Morphological features of early gallbladder carcinoma [J]. Hepatogastroenterology, 2012, 59 (116): 1013-7.
[8] Giang TH, Ngoc TT, Hassell LA. Carcinoma involving the gallbladder: a retrospective review of 23 cases - pitfalls in diagnosis of gallbladder carcinoma [J]. Diagn Pathol, 2012, 27 (7): 10-11.
[9] Hijioka S, Ikari T, et al. US - IDUS - EUS for diagnosis of biliary tract neoplasms [J]. Nihon Rinsho, 2006, 64 (1): 393-7.
[10] Konstantinidis IT, Bajpai S,et al. Gallbladder lesions identified on ultrasound. Lessons from the last 10 years [J]. J Gastrointest Surg, 2012, 16 (3): 549-53.
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  • APA Style

    Guotao Fang, Qi Zhang. (2017). Surgical Treatment and Prognosis Analysis of Primary Carcinoma of Gallbladder. Clinical Medicine Research, 6(3), 111-115. https://doi.org/10.11648/j.cmr.20170603.19

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    ACS Style

    Guotao Fang; Qi Zhang. Surgical Treatment and Prognosis Analysis of Primary Carcinoma of Gallbladder. Clin. Med. Res. 2017, 6(3), 111-115. doi: 10.11648/j.cmr.20170603.19

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    AMA Style

    Guotao Fang, Qi Zhang. Surgical Treatment and Prognosis Analysis of Primary Carcinoma of Gallbladder. Clin Med Res. 2017;6(3):111-115. doi: 10.11648/j.cmr.20170603.19

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  • @article{10.11648/j.cmr.20170603.19,
      author = {Guotao Fang and Qi Zhang},
      title = {Surgical Treatment and Prognosis Analysis of Primary Carcinoma of Gallbladder},
      journal = {Clinical Medicine Research},
      volume = {6},
      number = {3},
      pages = {111-115},
      doi = {10.11648/j.cmr.20170603.19},
      url = {https://doi.org/10.11648/j.cmr.20170603.19},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.cmr.20170603.19},
      abstract = {To discuss the effects of different treatment methods on the prognosis of primary carcinoma of gallbladder (PCG) patients. The clinical statistics of 99 cases of PCG patients were retrospectively analyzed, and the prognosis multivariate analysis was performed. Results: 52% of the patients suffered from PCG and gallstones simultaneously, and 82.8% (82/99) of the patients were diagnosed as PCG before surgeries. 86 cases of patients were subjected to routine exploratory surgeryies, and the radical resection rate was 33.72% (29/86). The overall 5-year survival rate was 6.28%, and the 1-year, 3-year and 5-year survival rates of the radical resection group were 78.43%, 48.49% and 23.77%, respectively. The results were significantly different from those of the palliative surgery group, the exploratory laparotomy group and the non-surgical group. The multivariate analysis of Cox model reveals that surgical method was significantly correlated with the invasion depth of tumor and the prognosis of gallbladder carcinoma. The treatment efficacy of PCG might be improved by increasing the early diagnosis rate and performing radical resection which are accompanied by radiotherapy and chemotherapy.},
     year = {2017}
    }
    

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  • TY  - JOUR
    T1  - Surgical Treatment and Prognosis Analysis of Primary Carcinoma of Gallbladder
    AU  - Guotao Fang
    AU  - Qi Zhang
    Y1  - 2017/05/04
    PY  - 2017
    N1  - https://doi.org/10.11648/j.cmr.20170603.19
    DO  - 10.11648/j.cmr.20170603.19
    T2  - Clinical Medicine Research
    JF  - Clinical Medicine Research
    JO  - Clinical Medicine Research
    SP  - 111
    EP  - 115
    PB  - Science Publishing Group
    SN  - 2326-9057
    UR  - https://doi.org/10.11648/j.cmr.20170603.19
    AB  - To discuss the effects of different treatment methods on the prognosis of primary carcinoma of gallbladder (PCG) patients. The clinical statistics of 99 cases of PCG patients were retrospectively analyzed, and the prognosis multivariate analysis was performed. Results: 52% of the patients suffered from PCG and gallstones simultaneously, and 82.8% (82/99) of the patients were diagnosed as PCG before surgeries. 86 cases of patients were subjected to routine exploratory surgeryies, and the radical resection rate was 33.72% (29/86). The overall 5-year survival rate was 6.28%, and the 1-year, 3-year and 5-year survival rates of the radical resection group were 78.43%, 48.49% and 23.77%, respectively. The results were significantly different from those of the palliative surgery group, the exploratory laparotomy group and the non-surgical group. The multivariate analysis of Cox model reveals that surgical method was significantly correlated with the invasion depth of tumor and the prognosis of gallbladder carcinoma. The treatment efficacy of PCG might be improved by increasing the early diagnosis rate and performing radical resection which are accompanied by radiotherapy and chemotherapy.
    VL  - 6
    IS  - 3
    ER  - 

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Author Information
  • The Second Ward Department of Oncology, Affiliated Hospital of Hebei University, Baoding, P. R. China

  • Department of Clinical Medicine, Medical College of HeBei University, Baoding, P. R. China

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