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Novel Discovery of the Relationship of Clinical Phenotype of Coronary Heart Disease with Retinol Binding Protein 4, Lipoprotein-Related Phospholipase A2

Received: 2 May 2017     Accepted: 18 May 2017     Published: 29 June 2017
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Abstract

To investigate the correlation between retinol binding protein 4 (RBP4), lipoprotein associated phospholipase A2 (LP-PLA2), we studied the clinical phenotype of coronary heart disease (CHD) and the severity of coronary artery disease. Our studies showed that the changes of retinol binding protein 4, LP-PLA2 serum concentration has a relation with the severity of coronary artery disease progression, but no clear relationship with the degree of coronary artery lesion and count. Furthermore, LP-PLA2 concentration increases with the increase of the severity of coronary artery disease and disease occurrences.

Published in Clinical Medicine Research (Volume 6, Issue 4)
DOI 10.11648/j.cmr.20170604.13
Page(s) 131-134
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2017. Published by Science Publishing Group

Keywords

Retinol Binding Protein 4, Lipoprotein Associated Phospholipase A2, Coronary Heart Disease, Coronary Artery Lesion Degree

References
[1] Guo Jifang, Kong Fanhe. Retinol binding protein 4 and coronary heart disease correlation. Mudanjiang Medical College, 2013, 34: 12-14.
[2] Maiolino G, Pedon L, Cesari M, et al. Lipoprotein-associated phospholipase A2 activity predicts cardiovascular events in high rick coronary artery disease patients. PLOS One, 2012, 7(10): e48171.
[3] Han Yaling. Chang'an International Cardiovascular Forum. Chinese percutaneous coronary intervention guidelines. Chinese Journal of Cardiology, 2012, 40 (4): 252-254.
[4] Li F, Xia K, Sheikh MS, et al. Retinol binding protein 4 promotes hyperinsulinism-induced proliferation of rat aortic smooth muscle cells, Mol Med Rep, 2014, 9 (5): 1634-1640.
[5] Ge Ling, Cheng Xunmin, YANG Song, et al. Retinol binding protein 4 and lipoprotein-associated phospholipase A2 levels and coronary heart disease and coronary artery disease characteristics of the correlation analysis. Bengbu Medical College, 40 (8): 1102-1104.
[6] Fortunato J, Bláha V, Bis J, et al. Lipoprotein-associated phospholipase A2 mass level is increased in elderly subjects with type 2 diabetes mellitus. J Diabetes Res, 2014, 2014: 278063.
[7] Caslake M J, Packard C J. Lipoprotein –associated phospholipase A2 (platelet-activating factoracetylhydrolase) and cardiovascular disease. Curr Opin Lipidol, 2003, 14 (4): 347-352.
[8] Zhao Yong, Guo Zhibin. The value of lipoprotein-associated phospholipase A2 in predicting the risk of coronary heart disease. Journal of Applied Clinical Medicine, 2014, 15 (12): 1-3.
[9] Ferguson J F, Hinkle CC, Mehta NN, et al. Translational studies of lipoprotein-associated phospholipase A2 in inflammation and atherosclerosis. J AM Coll Cardiol, 2012, 59 (8): 764-772.
[10] Liu Hai-liang, Li Guo-qing. Relationship between serum retinol-binding protein-4 and high-sensitivity C-reactive protein in patients with coronary heart disease. Journal of Clinical Internal Medicine, 2011, 28 (2): 92-94.
[11] Liu Xingjia, Zheng Xing, Qin Yongwen, et al. Lipoprotein-related phospholipase A2 activity in response to coronary angiography sclerosis degree, Journal of the Second Military Medical University, 2006, 27: 391-395.
[12] Cai A, Li G, Chen J, et al. Increased serum level of LP-PLA2 is independentiy associatated with the severity of coronary artery diseases: a cross-sectional study of Chinese population. BMC Cardiovasc Disord, 2015, 15 (1): 14.
[13] Wang Lili, Lei Changcheng. Lipoprotein-related phospholipase A2 and coronary heart disease related research progress. Modern Medicine and Health, 2015, 31 (1): 57-60.
[14] Pan Chen-liang, Peng Yu, Hu Xue-ting, et al. Correlation between lipoprotein-associated phospholipase A2 and acute syndromes. Clinical Cardiovascular Diseases, 2014, 30 (11): 962-965.
[15] Kolodgie F D, Burke A P, Skorija K S, et al. Lipoprotein –associated phospholipase A2 protein expression in the natural progression of human coronary atherosclerosis. Arterioscler Thromb Vasc Biol, 2006, 26: 2523-2529.
Cite This Article
  • APA Style

    Liu-qiang Lv, Yang-zhang Tang, Shi-qiang Wang, Gui Ren, Yu-Chen Lo, et al. (2017). Novel Discovery of the Relationship of Clinical Phenotype of Coronary Heart Disease with Retinol Binding Protein 4, Lipoprotein-Related Phospholipase A2. Clinical Medicine Research, 6(4), 131-134. https://doi.org/10.11648/j.cmr.20170604.13

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    ACS Style

    Liu-qiang Lv; Yang-zhang Tang; Shi-qiang Wang; Gui Ren; Yu-Chen Lo, et al. Novel Discovery of the Relationship of Clinical Phenotype of Coronary Heart Disease with Retinol Binding Protein 4, Lipoprotein-Related Phospholipase A2. Clin. Med. Res. 2017, 6(4), 131-134. doi: 10.11648/j.cmr.20170604.13

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    AMA Style

    Liu-qiang Lv, Yang-zhang Tang, Shi-qiang Wang, Gui Ren, Yu-Chen Lo, et al. Novel Discovery of the Relationship of Clinical Phenotype of Coronary Heart Disease with Retinol Binding Protein 4, Lipoprotein-Related Phospholipase A2. Clin Med Res. 2017;6(4):131-134. doi: 10.11648/j.cmr.20170604.13

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  • @article{10.11648/j.cmr.20170604.13,
      author = {Liu-qiang Lv and Yang-zhang Tang and Shi-qiang Wang and Gui Ren and Yu-Chen Lo and Hiroshi Honda and Edward J. Parish},
      title = {Novel Discovery of the Relationship of Clinical Phenotype of Coronary Heart Disease with Retinol Binding Protein 4, Lipoprotein-Related Phospholipase A2},
      journal = {Clinical Medicine Research},
      volume = {6},
      number = {4},
      pages = {131-134},
      doi = {10.11648/j.cmr.20170604.13},
      url = {https://doi.org/10.11648/j.cmr.20170604.13},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.cmr.20170604.13},
      abstract = {To investigate the correlation between retinol binding protein 4 (RBP4), lipoprotein associated phospholipase A2 (LP-PLA2), we studied the clinical phenotype of coronary heart disease (CHD) and the severity of coronary artery disease. Our studies showed that the changes of retinol binding protein 4, LP-PLA2 serum concentration has a relation with the severity of coronary artery disease progression, but no clear relationship with the degree of coronary artery lesion and count. Furthermore, LP-PLA2 concentration increases with the increase of the severity of coronary artery disease and disease occurrences.},
     year = {2017}
    }
    

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    AU  - Liu-qiang Lv
    AU  - Yang-zhang Tang
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    AU  - Gui Ren
    AU  - Yu-Chen Lo
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    AB  - To investigate the correlation between retinol binding protein 4 (RBP4), lipoprotein associated phospholipase A2 (LP-PLA2), we studied the clinical phenotype of coronary heart disease (CHD) and the severity of coronary artery disease. Our studies showed that the changes of retinol binding protein 4, LP-PLA2 serum concentration has a relation with the severity of coronary artery disease progression, but no clear relationship with the degree of coronary artery lesion and count. Furthermore, LP-PLA2 concentration increases with the increase of the severity of coronary artery disease and disease occurrences.
    VL  - 6
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Author Information
  • Department of Cardiovascular Medicine, Huaibei People’s Hospital, Huaibei, China

  • Department of Cardiovascular Medicine, Huaibei People’s Hospital, Huaibei, China

  • Department of Cardiovascular Medicine, Huaibei People’s Hospital, Huaibei, China

  • Department of Bioengineering, Northwestern Polytechnic University, Fremont, USA

  • Department of Bioengineering, Stanford University, Palo Alto, USA

  • Department of Bioengineering, Northwestern Polytechnic University, Fremont, USA

  • Department of Chemistry, Auburn University, Auburn, USA

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