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Hyperuricemia and Its Correlation with Target Organ Damage and Electrocardiographic Changes in Newly Diagnosed Adult Nigerian Hypertensive Patients

Received: 10 March 2017     Accepted: 10 April 2017     Published: 26 January 2018
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Abstract

The objective of the study was to determine the prevalence of Hyperuricemia and evaluate its correlation with target organ damage and electrocardiographic changes in newly diagnosed adult Nigerian hypertensive patients. It was a cross sectional study done at the University of Ilorin Teaching Hospital, Ilorin, Nigeria. 150 untreated newly diagnosed hypertensive patients 18 years and above and 115 age and sex-matched normotensive individuals were recruited into the study. Data obtained was analyzed using Epi-Info version 6.04 and Statistical Package for Social Sciences (SPSS) version 14 computer software packages. The prevalence of Hyperuricemia was 36.7% and 17.4% in hypertensive patients and normotensive controls respectively. Mean serum UA in hypertensive patients and normotensive controls was 0.4±0.1mmol/l and 0.3±0.1mmol/l respectively (p<0.0001). There was an association between Hyperuricemia and left ventricular hypertrophy (x2=23.97, p<0.0001). The study showed that Hyperuricemia is prevalent in adult Nigerians with newly diagnosed hypertension. Hyperuricemia was associated with left ventricular hypertrophy which is common target organ damage and confers an increased risk of cardiovascular events in systemic hypertension.

Published in Clinical Medicine Research (Volume 7, Issue 1)
DOI 10.11648/j.cmr.20180701.11
Page(s) 1-7
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2018. Published by Science Publishing Group

Keywords

Hyperuricemia, Target Organ Damage, Electrocardiographic Changes, Hypertensive Nigerians

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  • APA Style

    Abidemi Jude Fasae, Olusegun Adesola Busari, Rotimi Oluyombo, Musa Yusuf, Oladipo George Opadijo, et al. (2018). Hyperuricemia and Its Correlation with Target Organ Damage and Electrocardiographic Changes in Newly Diagnosed Adult Nigerian Hypertensive Patients. Clinical Medicine Research, 7(1), 1-7. https://doi.org/10.11648/j.cmr.20180701.11

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    ACS Style

    Abidemi Jude Fasae; Olusegun Adesola Busari; Rotimi Oluyombo; Musa Yusuf; Oladipo George Opadijo, et al. Hyperuricemia and Its Correlation with Target Organ Damage and Electrocardiographic Changes in Newly Diagnosed Adult Nigerian Hypertensive Patients. Clin. Med. Res. 2018, 7(1), 1-7. doi: 10.11648/j.cmr.20180701.11

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    AMA Style

    Abidemi Jude Fasae, Olusegun Adesola Busari, Rotimi Oluyombo, Musa Yusuf, Oladipo George Opadijo, et al. Hyperuricemia and Its Correlation with Target Organ Damage and Electrocardiographic Changes in Newly Diagnosed Adult Nigerian Hypertensive Patients. Clin Med Res. 2018;7(1):1-7. doi: 10.11648/j.cmr.20180701.11

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  • @article{10.11648/j.cmr.20180701.11,
      author = {Abidemi Jude Fasae and Olusegun Adesola Busari and Rotimi Oluyombo and Musa Yusuf and Oladipo George Opadijo and Ayodele Babatunde Omotoso},
      title = {Hyperuricemia and Its Correlation with Target Organ Damage and Electrocardiographic Changes in Newly Diagnosed Adult Nigerian Hypertensive Patients},
      journal = {Clinical Medicine Research},
      volume = {7},
      number = {1},
      pages = {1-7},
      doi = {10.11648/j.cmr.20180701.11},
      url = {https://doi.org/10.11648/j.cmr.20180701.11},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.cmr.20180701.11},
      abstract = {The objective of the study was to determine the prevalence of Hyperuricemia and evaluate its correlation with target organ damage and electrocardiographic changes in newly diagnosed adult Nigerian hypertensive patients. It was a cross sectional study done at the University of Ilorin Teaching Hospital, Ilorin, Nigeria. 150 untreated newly diagnosed hypertensive patients 18 years and above and 115 age and sex-matched normotensive individuals were recruited into the study. Data obtained was analyzed using Epi-Info version 6.04 and Statistical Package for Social Sciences (SPSS) version 14 computer software packages. The prevalence of Hyperuricemia was 36.7% and 17.4% in hypertensive patients and normotensive controls respectively. Mean serum UA in hypertensive patients and normotensive controls was 0.4±0.1mmol/l and 0.3±0.1mmol/l respectively (p2=23.97, p<0.0001). The study showed that Hyperuricemia is prevalent in adult Nigerians with newly diagnosed hypertension. Hyperuricemia was associated with left ventricular hypertrophy which is common target organ damage and confers an increased risk of cardiovascular events in systemic hypertension.},
     year = {2018}
    }
    

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  • TY  - JOUR
    T1  - Hyperuricemia and Its Correlation with Target Organ Damage and Electrocardiographic Changes in Newly Diagnosed Adult Nigerian Hypertensive Patients
    AU  - Abidemi Jude Fasae
    AU  - Olusegun Adesola Busari
    AU  - Rotimi Oluyombo
    AU  - Musa Yusuf
    AU  - Oladipo George Opadijo
    AU  - Ayodele Babatunde Omotoso
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    N1  - https://doi.org/10.11648/j.cmr.20180701.11
    DO  - 10.11648/j.cmr.20180701.11
    T2  - Clinical Medicine Research
    JF  - Clinical Medicine Research
    JO  - Clinical Medicine Research
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    EP  - 7
    PB  - Science Publishing Group
    SN  - 2326-9057
    UR  - https://doi.org/10.11648/j.cmr.20180701.11
    AB  - The objective of the study was to determine the prevalence of Hyperuricemia and evaluate its correlation with target organ damage and electrocardiographic changes in newly diagnosed adult Nigerian hypertensive patients. It was a cross sectional study done at the University of Ilorin Teaching Hospital, Ilorin, Nigeria. 150 untreated newly diagnosed hypertensive patients 18 years and above and 115 age and sex-matched normotensive individuals were recruited into the study. Data obtained was analyzed using Epi-Info version 6.04 and Statistical Package for Social Sciences (SPSS) version 14 computer software packages. The prevalence of Hyperuricemia was 36.7% and 17.4% in hypertensive patients and normotensive controls respectively. Mean serum UA in hypertensive patients and normotensive controls was 0.4±0.1mmol/l and 0.3±0.1mmol/l respectively (p2=23.97, p<0.0001). The study showed that Hyperuricemia is prevalent in adult Nigerians with newly diagnosed hypertension. Hyperuricemia was associated with left ventricular hypertrophy which is common target organ damage and confers an increased risk of cardiovascular events in systemic hypertension.
    VL  - 7
    IS  - 1
    ER  - 

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Author Information
  • Department of Internal Medicine, Federal Teaching Hospital, Ido-Ekiti, Nigeria

  • Department of Internal Medicine, Federal Teaching Hospital, Ido-Ekiti, Nigeria

  • Department of Internal Medicine, Federal Teaching Hospital, Ido-Ekiti, Nigeria

  • Department of Internal Medicine, Federal Teaching Hospital, Ido-Ekiti, Nigeria

  • Department of Internal Medicine, Ladoke Akintola University Teaching Hospital, Ogbomoso, Nigeria

  • Department of Internal Medicine, University of Ilorin Teaching Hospital, Ilorin, Nigeria

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