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Proteomics Based Mongolian Medicine Modified Sugmul-7 Mechanism of Regulating Endocrine Function in Hyperplasia of the Breast

Received: 14 January 2020     Accepted: 7 February 2020     Published: 14 February 2020
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Abstract

The aim of this study was to explore the mechanism of regulating the endocrine function of hyperplasia breast in rats with modified Mongolian medicine Sugmul-7 by proteomics, and provide experimental basis for its development and clinical application. Ninety female SD rats were randomly divided into normal group, model group, and modified Sugmul-7 low, medium, and high doses in a total of 5 groups. After the start of the experiment, each rat except the normal group was intraperitoneally injected with estradiol 25d and progesterone 6d at a standard dose of 0.3mg / kg for a total of 31 days. Four differential proteins were found through proteomic analysis, namely Ppp3cb, Cacybp, Gstz1Gstz1, and Nmd3 (and satisfying the standard conditions of 1.2 times to 0.8333 times) and found 5 related pathways. Mongolian medicine modified Sugmul-7 estradiol and progesterone-induced hyperplasia of the breast, Ppp3cb, Cacybp, Gstz1Gstz1, Nmd3 and other 4 differential proteins, through cGMP-PKG signal pathway, thyroid hormone signal pathway, estrogen signal pathway gastrointestinal signal related pathways, reproductive system related pathways, etc. regulate endocrine related pathways to treat the disease.

Published in Clinical Medicine Research (Volume 9, Issue 1)
DOI 10.11648/j.cmr.20200901.13
Page(s) 11-19
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2020. Published by Science Publishing Group

Keywords

Mongolian Medicine Modified Sugmul-7, Hyperplasia of the Breast, Endocrine Function, Proteomics

References
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  • APA Style

    Tong Shan, Tsend Ayushi, Tuul Khalzaibaast, Lian Bao Chen, Chao Lu Meng, et al. (2020). Proteomics Based Mongolian Medicine Modified Sugmul-7 Mechanism of Regulating Endocrine Function in Hyperplasia of the Breast. Clinical Medicine Research, 9(1), 11-19. https://doi.org/10.11648/j.cmr.20200901.13

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    ACS Style

    Tong Shan; Tsend Ayushi; Tuul Khalzaibaast; Lian Bao Chen; Chao Lu Meng, et al. Proteomics Based Mongolian Medicine Modified Sugmul-7 Mechanism of Regulating Endocrine Function in Hyperplasia of the Breast. Clin. Med. Res. 2020, 9(1), 11-19. doi: 10.11648/j.cmr.20200901.13

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    AMA Style

    Tong Shan, Tsend Ayushi, Tuul Khalzaibaast, Lian Bao Chen, Chao Lu Meng, et al. Proteomics Based Mongolian Medicine Modified Sugmul-7 Mechanism of Regulating Endocrine Function in Hyperplasia of the Breast. Clin Med Res. 2020;9(1):11-19. doi: 10.11648/j.cmr.20200901.13

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  • @article{10.11648/j.cmr.20200901.13,
      author = {Tong Shan and Tsend Ayushi and Tuul Khalzaibaast and Lian Bao Chen and Chao Lu Meng and Xing An and Ju Hua Gong and Wang Huan},
      title = {Proteomics Based Mongolian Medicine Modified Sugmul-7 Mechanism of Regulating Endocrine Function in Hyperplasia of the Breast},
      journal = {Clinical Medicine Research},
      volume = {9},
      number = {1},
      pages = {11-19},
      doi = {10.11648/j.cmr.20200901.13},
      url = {https://doi.org/10.11648/j.cmr.20200901.13},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.cmr.20200901.13},
      abstract = {The aim of this study was to explore the mechanism of regulating the endocrine function of hyperplasia breast in rats with modified Mongolian medicine Sugmul-7 by proteomics, and provide experimental basis for its development and clinical application. Ninety female SD rats were randomly divided into normal group, model group, and modified Sugmul-7 low, medium, and high doses in a total of 5 groups. After the start of the experiment, each rat except the normal group was intraperitoneally injected with estradiol 25d and progesterone 6d at a standard dose of 0.3mg / kg for a total of 31 days. Four differential proteins were found through proteomic analysis, namely Ppp3cb, Cacybp, Gstz1Gstz1, and Nmd3 (and satisfying the standard conditions of 1.2 times to 0.8333 times) and found 5 related pathways. Mongolian medicine modified Sugmul-7 estradiol and progesterone-induced hyperplasia of the breast, Ppp3cb, Cacybp, Gstz1Gstz1, Nmd3 and other 4 differential proteins, through cGMP-PKG signal pathway, thyroid hormone signal pathway, estrogen signal pathway gastrointestinal signal related pathways, reproductive system related pathways, etc. regulate endocrine related pathways to treat the disease.},
     year = {2020}
    }
    

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  • TY  - JOUR
    T1  - Proteomics Based Mongolian Medicine Modified Sugmul-7 Mechanism of Regulating Endocrine Function in Hyperplasia of the Breast
    AU  - Tong Shan
    AU  - Tsend Ayushi
    AU  - Tuul Khalzaibaast
    AU  - Lian Bao Chen
    AU  - Chao Lu Meng
    AU  - Xing An
    AU  - Ju Hua Gong
    AU  - Wang Huan
    Y1  - 2020/02/14
    PY  - 2020
    N1  - https://doi.org/10.11648/j.cmr.20200901.13
    DO  - 10.11648/j.cmr.20200901.13
    T2  - Clinical Medicine Research
    JF  - Clinical Medicine Research
    JO  - Clinical Medicine Research
    SP  - 11
    EP  - 19
    PB  - Science Publishing Group
    SN  - 2326-9057
    UR  - https://doi.org/10.11648/j.cmr.20200901.13
    AB  - The aim of this study was to explore the mechanism of regulating the endocrine function of hyperplasia breast in rats with modified Mongolian medicine Sugmul-7 by proteomics, and provide experimental basis for its development and clinical application. Ninety female SD rats were randomly divided into normal group, model group, and modified Sugmul-7 low, medium, and high doses in a total of 5 groups. After the start of the experiment, each rat except the normal group was intraperitoneally injected with estradiol 25d and progesterone 6d at a standard dose of 0.3mg / kg for a total of 31 days. Four differential proteins were found through proteomic analysis, namely Ppp3cb, Cacybp, Gstz1Gstz1, and Nmd3 (and satisfying the standard conditions of 1.2 times to 0.8333 times) and found 5 related pathways. Mongolian medicine modified Sugmul-7 estradiol and progesterone-induced hyperplasia of the breast, Ppp3cb, Cacybp, Gstz1Gstz1, Nmd3 and other 4 differential proteins, through cGMP-PKG signal pathway, thyroid hormone signal pathway, estrogen signal pathway gastrointestinal signal related pathways, reproductive system related pathways, etc. regulate endocrine related pathways to treat the disease.
    VL  - 9
    IS  - 1
    ER  - 

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Author Information
  • Affiliated Hospital of Inner Mongolia University for Nationalities, Tongliao, China

  • Mongolian Medical Research Center, International school of Mongolian Traditional Medicine, MNUMS, Ulaanbaatar, Mongolia

  • Traditional Medicine Department, Mongolian University Pharmaceutical Sciences, Ulaanbaatar, Mongolia

  • Mongolian Medicine and Pharmaceutical School of Inner Mongolia University of Nationalities, Tongliao, China

  • Mongolian Medicine and Pharmaceutical School of Inner Mongolia University of Nationalities, Tongliao, China

  • Mongolian Medicine and Pharmaceutical School of Inner Mongolia University of Nationalities, Tongliao, China

  • Traditional Chinese Medicine (Mongolian Medicine), Inner Mongolia University for Nationalities, Tongliao, China

  • Mongolian Medicine and Pharmaceutical School of Inner Mongolia University for Nationalities, Mongolian Pharmacology Laboratory, Tongliao, China

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