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Bone Marrow Metastases as an Initial Presentation of Gastrointestinal Adenocarcinoma: A Case Report

Received: 13 February 2017     Accepted: 24 April 2017     Published: 14 June 2017
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Abstract

Bone marrow metastases as the initial presentation of a solid tumour are uncommon, especially if the primary neoplasm site cannot be identified during the diagnosis presentation despite laboratory testing and imaging techniques. In these situations, bone marrow examination can lead to a final diagnosis of the primary malignancy. We report an unusual case of osteoblastic metastases from an unknown primary site – this was because no relevant lesions were found from either imaging or endoscopic examination. The patient was sent for a bone marrow biopsy, revealing a morphology replaced by glandular structures and an immunohistochemistry consistent with a gastrointestinal origin. Bone marrow examination was the clue to the final diagnosis and led to specific treatment.

Published in Clinical Medicine Research (Volume 6, Issue 4)
DOI 10.11648/j.cmr.20170604.12
Page(s) 127-130
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2017. Published by Science Publishing Group

Keywords

Bone Marrow, Metastases, Solid Tumour, Immunohistochemistry

References
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Cite This Article
  • APA Style

    Molina-Arrebola María-Angustias, Fernández-Caballero Mariana, Avivar-Oyonarte Cristóbal, Jiménez-Cortés María-Carmen, Hidalgo-Rico María-Angeles. (2017). Bone Marrow Metastases as an Initial Presentation of Gastrointestinal Adenocarcinoma: A Case Report. Clinical Medicine Research, 6(4), 127-130. https://doi.org/10.11648/j.cmr.20170604.12

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    ACS Style

    Molina-Arrebola María-Angustias; Fernández-Caballero Mariana; Avivar-Oyonarte Cristóbal; Jiménez-Cortés María-Carmen; Hidalgo-Rico María-Angeles. Bone Marrow Metastases as an Initial Presentation of Gastrointestinal Adenocarcinoma: A Case Report. Clin. Med. Res. 2017, 6(4), 127-130. doi: 10.11648/j.cmr.20170604.12

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    AMA Style

    Molina-Arrebola María-Angustias, Fernández-Caballero Mariana, Avivar-Oyonarte Cristóbal, Jiménez-Cortés María-Carmen, Hidalgo-Rico María-Angeles. Bone Marrow Metastases as an Initial Presentation of Gastrointestinal Adenocarcinoma: A Case Report. Clin Med Res. 2017;6(4):127-130. doi: 10.11648/j.cmr.20170604.12

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  • @article{10.11648/j.cmr.20170604.12,
      author = {Molina-Arrebola María-Angustias and Fernández-Caballero Mariana and Avivar-Oyonarte Cristóbal and Jiménez-Cortés María-Carmen and Hidalgo-Rico María-Angeles},
      title = {Bone Marrow Metastases as an Initial Presentation of Gastrointestinal Adenocarcinoma: A Case Report},
      journal = {Clinical Medicine Research},
      volume = {6},
      number = {4},
      pages = {127-130},
      doi = {10.11648/j.cmr.20170604.12},
      url = {https://doi.org/10.11648/j.cmr.20170604.12},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.cmr.20170604.12},
      abstract = {Bone marrow metastases as the initial presentation of a solid tumour are uncommon, especially if the primary neoplasm site cannot be identified during the diagnosis presentation despite laboratory testing and imaging techniques. In these situations, bone marrow examination can lead to a final diagnosis of the primary malignancy. We report an unusual case of osteoblastic metastases from an unknown primary site – this was because no relevant lesions were found from either imaging or endoscopic examination. The patient was sent for a bone marrow biopsy, revealing a morphology replaced by glandular structures and an immunohistochemistry consistent with a gastrointestinal origin. Bone marrow examination was the clue to the final diagnosis and led to specific treatment.},
     year = {2017}
    }
    

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    T1  - Bone Marrow Metastases as an Initial Presentation of Gastrointestinal Adenocarcinoma: A Case Report
    AU  - Molina-Arrebola María-Angustias
    AU  - Fernández-Caballero Mariana
    AU  - Avivar-Oyonarte Cristóbal
    AU  - Jiménez-Cortés María-Carmen
    AU  - Hidalgo-Rico María-Angeles
    Y1  - 2017/06/14
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    N1  - https://doi.org/10.11648/j.cmr.20170604.12
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    AB  - Bone marrow metastases as the initial presentation of a solid tumour are uncommon, especially if the primary neoplasm site cannot be identified during the diagnosis presentation despite laboratory testing and imaging techniques. In these situations, bone marrow examination can lead to a final diagnosis of the primary malignancy. We report an unusual case of osteoblastic metastases from an unknown primary site – this was because no relevant lesions were found from either imaging or endoscopic examination. The patient was sent for a bone marrow biopsy, revealing a morphology replaced by glandular structures and an immunohistochemistry consistent with a gastrointestinal origin. Bone marrow examination was the clue to the final diagnosis and led to specific treatment.
    VL  - 6
    IS  - 4
    ER  - 

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Author Information
  • Department of Biotechnology, Haematology and Haemotherapy Unit, Poniente Hospital, Almería, Spain

  • Department of Biotechnology, Haematology and Haemotherapy Unit, Poniente Hospital, Almería, Spain

  • Department of Biotechnology, Poniente Hospital, Almería, Spain

  • Department of Biotechnology, Pathology Unit, Poniente Hospital, Almería, Spain

  • Department of Internal Medicine, Pulmonology Unit, Poniente Hospital, Almería, Spain

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